Author’s response to reviews Title: Transgenerational effects of polychlorinated biphenyls: 1. Development and physiology across 3 generations of rats Authors:
نویسندگان
چکیده
The experiment examined the effects of prenatal exposure to the PCB mixture Aroclor-1221 on several parameters in the F1, F2, and F3 generations in Sprague-Dawley rats. Only a few effects were found in the F2 and F3 generations and most were in the maternal lineage, not the paternal lineage. The effects were on body weight (5-10%) and plasma progesterone in the F2s and progesterone and estrogen in the F3s. No genetic or epigenetic data are presented. The paper is nicely written, the sample sizes appear reasonable but not necessarily optimal for detecting effects across 3 generations given how subtle they are likely to be and one wonders if a study such as this shouldn't be as highly powered as feasibility would allow. It is not clear that the data were appropriately analyzed.
منابع مشابه
Transgenerational effects of polychlorinated biphenyls: 1. Development and physiology across 3 generations of rats
BACKGROUND Polychlorinated biphenyls (PCBs) are persistent organic environmental contaminants and known endocrine-disrupting chemicals (EDCs). Previous studies demonstrated that developmental exposure to the weakly estrogenic PCB mixture Aroclor 1221 (A1221) in Sprague-Dawley rats altered sexual development, adult reproductive physiology and body weight. The current study tested the hypothesis ...
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